Maxwell Biotech Group currently has 9 biotech companies in its portfolio, which are engaged in the development of 11 innovative clinical stage drugs. 


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Product: OС000459, selective antagonist of CRTH2 receptors

Therapeutic focus: asthma and other respiratory diseases: allergic rhinitis, conjunctivitis, atopic dermatitis, and eosinophilic esophagitis.

Status: Phase 3 clinical trials.

Partner: Oxagen, Ltd., Atopix Therapeutics (UK)

Description:  OC000459 is a safe low molecular compound that comes in one-a-day oral tablets for the treatment of moderate to severe asthma and other respiratory diseases.

OC000459’s innovative mechanism is unique in its highly selective binding to a specific receptor, blocking pathogenesis at an early stage and reducing eosinophilic inflammation which plays a key role in the development of chronic allergic respiratory diseases. Due to this mechanism, the drug is more selective with respect to a specific inflammatory response and devoid of local and systemic side effects of glucocorticoid therapy.


Currently preclinical and 1/2 clinical trials have been successfully conducted and shown a high efficacy and safety.

At the present time the company is due to complete a phase 3 clinical trial in patients with atopic eosinophilic asthma within the drug registration procedure in Russia. 16 biggest Russian clinical sites are participating within the clinical study.



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